The reference site for Treosulfan

Treosulfan is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents.

WHAT IS Treosulfan?

Treosulfan is one of a group of anti-cancer medicines called ‘alkylating agents’, which works by preventing the growth and division of cells and therefore stops them increasing in numbers.

This medication is commonly used as a chemotherapy drug to treat ovarian cancer. Doctors also sometimes use it in high doses to treat people with leukaemia who are going to have a donor bone marrow or stem cell transplant.

Additionally, treosulfan is currently used in clinical trials on patients who desire to try a new treatment approach.


Brand Name(s): NSC 39069
CAS nº: 299-75-2


Product Info

The sections below will provide you with more specific information and guidelines related to treosulfan and its correct use. Please read them carefully.

FDA Information

Treosulfan is under clinical development and has not yet received approval from the US FDA. However, it is currently being used in clinical trials on patients who desire to try a new treatment approach.

In Europe, treosulfan is already commercially available for the treatment of ovarian cancer.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Treosulfan is an alkylating agent. It works by preventing the growth and division of cells and therfore stops them increasing in numbers.

It is most commonly used as a chemotherapy drug in the treatment of ovarian cancer. Doctors also sometimes use it in high doses to treat people with leukaemia who are going to have a donor bone marrow or stem cell transplant.

Other uses for this medicine

Treosulfan is undergoing clinical trials and is currently not available on the US market. Therefore, the alternative uses for this medication have not been fully defined yet.

This section will be updated following further clinical developments.

Dosage and using this medicine

Treosulfan comes as an injection or as a capsule (250 mg).

The injection can be given into a tube in a vein (intravenously), through a central line or by injection straight into the tummy (abdomen).

You usually have chemotherapy as a course of several cycles of treatment. The treatment plan for treosulfan depends on which cancer you are being treated for.

Treosulfan occasionally causes you to feel or be sick. It is important to keep taking this medicine at regular dosage times even if you begin to feel unwell.

Swallow treosulfan capsules whole, not crushed or chewed, with a glass of water.

After treosulfan has been taken or administered, it is recommended to drink more fluids and up to 24 hours after.

If you vomit shortly after taking a dose, check with your doctor.

This medicine is for you. Never give it to others even if their condition appears to be the same as yours.

What special precautions should I follow?


Tell your doctor if you have ever had an allergic reaction to treosulfan or any other medicine.

Moreover, please inform your doctor if you are receiving radiotherapy treatment with other anti-cancer chemotherapy. Also tell your doctor if your bone marrow does not function properly.

Also, tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and other over the counter remedies – drugs can react together.

Fertility – Your ability to become pregnant or father a child may be affected by taking this drug. It is important to discuss fertility with your doctor before starting treatment.

Contraception – It is not advisable to become pregnant or father a child while taking treosulfan, as the developing foetus may be harmed. It is important to use effective contraception while taking this drug, and for at least a few months afterwards. Again, discuss this with your doctor.

Because of nausea and vomiting the ability to drive or operate machines may be influenced.

What should I do if I forget a dose?

Treosulfan is still undergoing clinical trials in the US, and patients who are administered this medication are under specific supervision in a hospital.

Once this medication has received FDA approval and is commercially available, the information regarding a missed dose will be included in this section.

What side effects can this medication cause?

Each person’s reaction to chemotherapy is different. Some people have very few side effects, while others may experience more. The side effects described in this information will not affect everyone who is given treosulfan, and may be different if you are having more than one chemotherapy drug.

We have outlined the most common and less common side effects, so that you can be aware of them if they occur. However, we have not included those that are very rare and therefore extremely unlikely to affect you. If you notice any effects which you think may be due to the drug, but which are not listed in this information, please discuss them with your doctor or chemotherapy nurse.

Lowered resistance to infection – Treosulfan can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin seven days after treatment has been given, and your resistance to infection usually reaches its lowest point 10–14 days after chemotherapy. Your blood cells will then increase steadily and will usually have returned to normal levels before your next cycle of chemotherapy is due.

Contact your doctor or the hospital straightaway if:

– Your temperature goes above 38ºC (100.5ºF)
– You suddenly feel unwell (even with a normal temperature) or if you have an allergic reaction

You will have a blood test before having more chemotherapy to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if the number of blood cells (the blood count) is still low.

Bruising or bleeding – Treosulfan can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding.

Anaemia (low number of red blood cells) – While having treatment with treosulfan you may become anaemic. This may make you feel tired and breathless. Let your doctor or nurse know if these are a problem.

Skin changes – Treosulfan can cause a rash, which may be itchy. Your doctor can prescribe medicine to help with this. Your skin may darken due to excess production of pigment. This usually returns to normal a few months after the treatment has finished.

Tiredness and a general feeling of weakness – It is important to allow yourself plenty of time to rest.

Less common side effects include:

Nausea (feeling sick) and vomiting – If you do feel sick it may begin soon after the treatment is given and can last for about a day. Your doctor can now prescribe very effective anti-sickness (anti-emetic) drugs to prevent or greatly reduce nausea and vomiting. If the sickness is not controlled or continues tell your doctor, who can prescribe other anti-sickness drugs that may be more effective.

Hair loss
 – It is very unusual to lose your hair. Some people notice that their hair becomes a little thinner, but not usually enough to be noticeable to other people.

Irritation of the bladder – It is important to drink plenty of fluids for up to 24 hours after your chemotherapy to help prevent any irritation.

What storage conditions are needed for this medicine?

Treosulfan is currently only available in clinical trials, and the hospital where a patient is being administered treosulfan is responsible for storing this medication correctly.

Patient information related to storage conditions necessary for this medication will be provided once it has received FDA approval and is available in the US market.

In case of an emergency/overdose

Although there is no experience of acute overdosage with treosulfan, nausea, vomiting and gastritis may occur.

Prolonged or excessive therapeutic doses may result in bone marrow depression which has occasionally been irreversible. The drug should be withdrawn, a blood transfusion given and general supportive measures provided.

However, as this medication is given in a hospital setting, you should speak with your doctor or nurse if you suspect of an overdose.

Product Images


Treosulfan is currently used in clinical trials, and no forms or images of this medication are presently available.

Following its approval by the FDA, this section will provide you with images and specific information on the principal types of treosulfan that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.


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